Function introduction:
In the RCD type-based query, users can query a programmed cell death type of interest, and then RCDdb will return all of these types of annotations include pathway enrichment, disease, drug protein, and transcriptional expression levels.
Explanation of example:
The main process of Cuproptosis depends on the accumulation of copper ions inside cells.Copper ions directly bind to acylated components in the tricarboxylic acid (TCA) cycle, causing these proteins to aggregate and become disordered, blocking the TCA cycle and triggering protein toxicity stress and inducing cell death.
Function introduction:
In the RCD gene-based query, users can query a RCD gene of interest, and then RCDdb will return all annotations for that gene, include disease, drug, protein, and transcriptional expression levels.
Parameter explanation:
Input gene name: Input the gene of interest, including a total of 1849 genes.
Explanation of example:
AR is related to apoptosis through post-translational modifications.In rodents,the AR and its C-terminal portion regulate apoptosis through the p53 pathway.Inhibition of AR leads to the cell cycle entering apoptosis.In humans,AR also regulates apoptosis in cell lines that overexpress AR.;Furthermore, overexpression of AR prevented ferroptosis in the presence of GPX4.
Function introduction:
Based on the cancer query, users can query all RCD gene with a particular type of cancer.
On the right is an overview of the data for 33 types of cancer and the percentage of cancers that contain RCD Signature genes.
Parameter explanation:
Cancer name : Select the cancer of interest that supported in this database,which format is abbreviated in TCGA,like BLCA.
